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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesRattus norvegicus (Rat)
GeneHtr1a
Synonym5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT1A
ADRB2RL1
ADRBRL1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length422
Amino acid sequenceMDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProtP19327
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL273
IUPHAR1
DrugBankN/A

Ligand

NameCHEMBL135011
Molecular formulaC16H23NO2
IUPAC name2-[(cyclohexylamino)methyl]-3,4-dihydro-2H-chromen-7-ol
Molecular weight261.365
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.4
SynonymsBDBM50061672
2-Cyclohexylaminomethyl-chroman-7-ol; oxalic acid
CHEMBL1180608
Inchi KeyAFXVAXQMGUXVBX-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H23NO2/c18-14-8-6-12-7-9-15(19-16(12)10-14)11-17-13-4-2-1-3-5-13/h6,8,10,13,15,17-18H,1-5,7,9,11H2
PubChem CID10563379
ChEMBLN/A
IUPHARN/A
BindingDB50061672
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki330.0 nMPMID9435894BindingDB

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