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Name | D(2) dopamine receptor |
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Species | Mus musculus (Mouse) |
Gene | Drd2 |
Synonym | D2 receptor D2(415) and D2(444) D2A and D2B D2R dopamine D2 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 444 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC |
UniProt | P61168 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3427 |
IUPHAR | 215 |
DrugBank | N/A |
Name | CHEMBL136877 |
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Molecular formula | C17H25NO2 |
IUPAC name | [4-[[1-(cyclopropylmethyl)piperidin-4-yl]methoxy]phenyl]methanol |
Molecular weight | 275.392 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 2.5 |
Synonyms | 4-[[4-(Hydroxymethyl)phenoxy]methyl]-1-(cyclopropylmethyl)piperidine CHEMBL1180660 [4-(1-Cyclopropylmethyl-piperidin-4-ylmethoxy)-phenyl]-methanol;0.3hydrate BDBM50002299 ZINC13730019 |
Inchi Key | DRHLUSIUCNGTDR-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H25NO2/c19-12-15-3-5-17(6-4-15)20-13-16-7-9-18(10-8-16)11-14-1-2-14/h3-6,14,16,19H,1-2,7-13H2 |
PubChem CID | 10356045 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50002299 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | PMID1360026 | BindingDB |
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