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Name | D(2) dopamine receptor |
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Species | Mus musculus (Mouse) |
Gene | Drd2 |
Synonym | D2 receptor D2(415) and D2(444) D2A and D2B D2R dopamine D2 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 444 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC |
UniProt | P61168 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3427 |
IUPHAR | 215 |
DrugBank | N/A |
Name | CHEMBL337148 |
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Molecular formula | C21H25NO2S |
IUPAC name | 2-(1-benzylpiperidin-4-yl)-1-(4-methylsulfinylphenyl)ethanone |
Molecular weight | 355.496 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 2.9 |
Synonyms | 2-(1-Benzyl-piperidin-4-yl)-1-(4-methanesulfinyl-phenyl)-ethanone;0.25hydrate BDBM50002214 SCHEMBL7382593 4'-(Methylsulfinyl)-omega-(1-benzylpiperidin-4-yl)acetophenone CHEMBL1184177 |
Inchi Key | FDANJYRCEXIYKH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H25NO2S/c1-25(24)20-9-7-19(8-10-20)21(23)15-17-11-13-22(14-12-17)16-18-5-3-2-4-6-18/h2-10,17H,11-16H2,1H3 |
PubChem CID | 10021122 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50002214 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | PMID1360026 | BindingDB |
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