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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	diethyl (4-bromobenzylidene)malonate
Molecular formula	C14H15BrO4
IUPAC name	diethyl 2-[(4-bromophenyl)methylidene]propanedioate
Molecular weight	327.174
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.0
Synonyms	propanedioic acid, [(4-bromophenyl)methylene]-, diethyl ester 4-Bromobenzylidenemalonic acid diethyl ester CHEMBL1362503 DTXSID20327206 SR-01000076616 AC1Q25ZX MCULE-2388705769 NSC-637153 ZINC1625052 2-[(4-bromophenyl)methylidene]propanedioic acid diethyl ester BDBM62222 diethyl 2-[(4-bromophenyl)methylidene]propanedioate SCHEMBL1673521 cid_367432 HMS2886H18 SR-01000076616-1 2-(4-bromo-benzylidene)-malonic acid diethyl ester AFYSUDAWCPZFEQ-UHFFFAOYSA-N Diethyl 2-(4-bromobenzylidene)malonate MLS000756785 NSC637153 22399-01-5 DNDI1417400 SMR000529064 AC1L7UX4 CTK0J6440 InChI=1/C14H15BrO4/c1-3-18-13(16)12(14(17)19-4-2)9-10-5-7-11(15)8-6-10/h5-9H,3-4H2,1-2H MolPort-003-722-669 SR-01000076616-3 2-(4-bromobenzylidene)malonic acid diethyl ester AKOS002134081 diethyl 2-[(4-bromophenyl)methylene]propanedioate [ Show all ]
Inchi Key	AFYSUDAWCPZFEQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H15BrO4/c1-3-18-13(16)12(14(17)19-4-2)9-10-5-7-11(15)8-6-10/h5-9H,3-4H2,1-2H3
PubChem CID	367432
ChEMBL	CHEMBL1362503
IUPHAR	N/A
BindingDB	62222
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10000.0 nM	PubChem BioAssay data set	ChEMBL

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