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GPCR

NameN-formyl peptide receptor 2
SpeciesHomo sapiens (Human)
GeneFPR2
SynonymFPRH1
FPRH2
FPRL1
HM63
Lipoxin A4 receptor
[ Show all ]
DiseaseN/A
Length351
Amino acid sequenceMETNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProtP25090
Protein Data BankN/A
GPCR-HGmod modelP25090
3D structure modelThis predicted structure model is from GPCR-EXP P25090.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4227
IUPHAR223
DrugBankN/A

Ligand

NameUNM000003546901
Molecular formulaC21H10ClF3O5
IUPAC name[3-(2-chlorophenyl)-4-oxo-2-(trifluoromethyl)chromen-7-yl] furan-2-carboxylate
Molecular weight434.751
Hydrogen bond acceptor8
Hydrogen bond donor0
XlogP5.5
SynonymsAKOS001646042
furan-2-carboxylic acid [3-(2-chlorophenyl)-4-keto-2-(trifluoromethyl)chromen-7-yl] ester
ZINC706941
2-furancarboxylic acid [3-(2-chlorophenyl)-4-oxo-2-(trifluoromethyl)-1-benzopyran-7-yl] ester
MolPort-000-661-391
[ Show all ]
Inchi KeyCNVUPTMAMYTSKJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H10ClF3O5/c22-14-5-2-1-4-12(14)17-18(26)13-8-7-11(29-20(27)15-6-3-9-28-15)10-16(13)30-19(17)21(23,24)25/h1-10H
PubChem CID1036526
ChEMBLCHEMBL1551148
IUPHARN/A
BindingDB40415
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<66700.0 nMN/ABindingDB
Ki<40300.0 nMN/ABindingDB

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