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GPCR

NameG-protein coupled receptor 183
SpeciesHomo sapiens (Human)
GeneGPR183
SynonymEBI2 {ECO:0000303|PubMed:8383238}
lymphocyte-specific G protein-coupled receptor
hEBI2 {ECO:0000303|PubMed:22875855}
GPR183
G protein-coupled receptor 183
[ Show all ]
DiseaseN/A
Length361
Amino acid sequenceMDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProtP32249
Protein Data BankN/A
GPCR-HGmod modelP32249
3D structure modelThis predicted structure model is from GPCR-EXP P32249.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3259470
IUPHAR81
DrugBankN/A

Ligand

NameCHEMBL3560573
Molecular formulaC20H19BrF2N2O
IUPAC name(E)-3-(4-bromophenyl)-1-[4-[(3,5-difluorophenyl)methyl]piperazin-1-yl]prop-2-en-1-one
Molecular weight421.286
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.0
SynonymsSCHEMBL16598638
SCHEMBL16598641
MLS-0472535.0001
Inchi KeyALWZDEOVAJDSBI-ZZXKWVIFSA-N
Inchi IDInChI=1S/C20H19BrF2N2O/c21-17-4-1-15(2-5-17)3-6-20(26)25-9-7-24(8-10-25)14-16-11-18(22)13-19(23)12-16/h1-6,11-13H,7-10,14H2/b6-3+
PubChem CID73330398
ChEMBLCHEMBL3560573
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502.21 nMPubChem BioAssay data setChEMBL

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