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GLASS

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GPCR

Name	Metabotropic glutamate receptor 3
Species	Rattus norvegicus (Rat)
Gene	Grm3
Synonym	mGluR3 mGlu3 receptor GPRC1C glutamate receptor
Disease	N/A for non-human GPCRs
Length	879
Amino acid sequence	MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProt	P31422
Protein Data Bank	2e4u, 2e4v, 2e4w, 2e4x, 2e4y
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2e4u.
BioLiP	BL0086116,BL0086117, BL0086120,BL0086121, BL0086118,BL0086119, BL0086114,BL0086115, BL0086112,BL0086113
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3067
IUPHAR	291
DrugBank	N/A

Ligand

Name	CHEMBL3617505
Molecular formula	C20H17ClFN3O2
IUPAC name	(7R)-2-[(4-chlorophenoxy)methyl]-5-(4-fluorophenyl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
Molecular weight	385.823
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.9
Synonyms	BDBM50122298
Inchi Key	BLLHYNOHSXJZLV-CYBMUJFWSA-N
Inchi ID	InChI=1S/C20H17ClFN3O2/c1-13-11-24(17-6-4-15(22)5-7-17)20(26)19-10-16(23-25(13)19)12-27-18-8-2-14(21)3-9-18/h2-10,13H,11-12H2,1H3/t13-/m1/s1
PubChem CID	122190321
ChEMBL	CHEMBL3617505
IUPHAR	N/A
BindingDB	50122298
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	1.86 %	PMID26335039	ChEMBL
IC50	1170.0 nM	PMID26335039	BindingDB,ChEMBL
IC50	1174.9 nM	PMID26335039	ChEMBL
IC50	1175.0 nM	PMID26335039	BindingDB

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