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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL3616586
Molecular formula	C37H35F3N2O5
IUPAC name	3-[[4-[1-[6-(4-methoxyphenyl)-3-[2-methoxy-5-(trifluoromethyl)phenyl]indol-1-yl]butyl]benzoyl]amino]propanoic acid
Molecular weight	644.691
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	7.7
Synonyms	BDBM50120317
Inchi Key	BZGPVCYWDARBEG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C37H35F3N2O5/c1-4-5-32(24-6-8-25(9-7-24)36(45)41-19-18-35(43)44)42-22-31(30-21-27(37(38,39)40)13-17-34(30)47-3)29-16-12-26(20-33(29)42)23-10-14-28(46-2)15-11-23/h6-17,20-22,32H,4-5,18-19H2,1-3H3,(H,41,45)(H,43,44)
PubChem CID	122189575
ChEMBL	CHEMBL3616586
IUPHAR	N/A
BindingDB	50120317
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8.0 nM	PMID26303893	ChEMBL
IC50	8.0 nM	PMID26303893	BindingDB
IC50	130.0 nM	PMID26303893	BindingDB,ChEMBL

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