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Name | Orexin receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | HCRTR2 |
Synonym | Ox-2-R OX2 receptor Ox2-R OX2R orexin receptor type 2 [ Show all ] |
Disease | Insomnia |
Length | 444 |
Amino acid sequence | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW |
UniProt | O43614 |
Protein Data Bank | 5ws3, 5wqc, 4s0v, 4rnb |
GPCR-HGmod model | O43614 |
3D structure model | This structure is from PDB ID 5ws3. |
BioLiP | BL0303710, BL0398950, BL0397818, BL0302679 |
Therapeutic Target Database | T69485 |
ChEMBL | CHEMBL4792 |
IUPHAR | 322 |
DrugBank | BE0005865 |
Name | CHEMBL3669032 |
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Molecular formula | C24H24N6O2 |
IUPAC name | [(2S,3R)-3-(1,3-benzoxazol-2-ylamino)-2-methylpiperidin-1-yl]-(6-methyl-3-pyrimidin-2-ylpyridin-2-yl)methanone |
Molecular weight | 428.496 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 3.8 |
Synonyms | BDBM175179 SCHEMBL16031635 US9115117, 81 |
Inchi Key | CEZCPRMJAIZSLB-FUHWJXTLSA-N |
Inchi ID | InChI=1S/C24H24N6O2/c1-15-10-11-17(22-25-12-6-13-26-22)21(27-15)23(31)30-14-5-8-18(16(30)2)28-24-29-19-7-3-4-9-20(19)32-24/h3-4,6-7,9-13,16,18H,5,8,14H2,1-2H3,(H,28,29)/t16-,18+/m0/s1 |
PubChem CID | 90405452 |
ChEMBL | CHEMBL3669032 |
IUPHAR | N/A |
BindingDB | 175179 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 100.0 nM | , None | BindingDB,ChEMBL |
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