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GPCR

NameG-protein coupled receptor 183
SpeciesHomo sapiens (Human)
GeneGPR183
SynonymEBI2 {ECO:0000303|PubMed:8383238}
lymphocyte-specific G protein-coupled receptor
hEBI2 {ECO:0000303|PubMed:22875855}
GPR183
G protein-coupled receptor 183
[ Show all ]
DiseaseN/A
Length361
Amino acid sequenceMDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProtP32249
Protein Data BankN/A
GPCR-HGmod modelP32249
3D structure modelThis predicted structure model is from GPCR-EXP P32249.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3259470
IUPHAR81
DrugBankN/A

Ligand

NameAC1OX4NE
Molecular formulaC20H18FN3O3S
IUPAC name2-[4-[(E)-3-(4-fluorophenyl)prop-2-enoyl]piperazin-1-yl]sulfonylbenzonitrile
Molecular weight399.44
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.2
SynonymsCHEMBL3560541
SCHEMBL16598742
AKOS008442197
MLS-0472472.0001
2-[4-[(E)-3-(4-fluorophenyl)prop-2-enoyl]piperazin-1-yl]sulfonylbenzonitrile
[ Show all ]
Inchi KeyCWCUXMQIVLLWDM-JXMROGBWSA-N
Inchi IDInChI=1S/C20H18FN3O3S/c21-18-8-5-16(6-9-18)7-10-20(25)23-11-13-24(14-12-23)28(26,27)19-4-2-1-3-17(19)15-22/h1-10H,11-14H2/b10-7+
PubChem CID7942116
ChEMBLCHEMBL3560541
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5048.2 nMPubChem BioAssay data setChEMBL

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