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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1F
Species	Homo sapiens (Human)
Gene	HTR1F
Synonym	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled serotonin receptor 1F 5-HT-1F 5-HT1Ebeta HTR1EL 5-HT1F 5-HT1F receptor 5-HT6 [ Show all ]
Disease	Migraine
Length	366
Amino acid sequence	MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
UniProt	P30939
Protein Data Bank	N/A
GPCR-HGmod model	P30939
3D structure model	This predicted structure model is from GPCR-EXP P30939.
BioLiP	N/A
Therapeutic Target Database	T78656
ChEMBL	CHEMBL1805
IUPHAR	5
DrugBank	BE0000460, BE0004958

Ligand

Name	CHEMBL3617549
Molecular formula	C20H21FN2O2
IUPAC name	4-fluoro-N-[3-(1-methylpiperidine-4-carbonyl)phenyl]benzamide
Molecular weight	340.398
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.0
Synonyms	L022750 SCHEMBL5210537 BDBM50119543 DHGAOXXHXZSEGT-UHFFFAOYSA-N 4-[3-(4-fluorobenzamidyl)benzoyl]-1-methylpiperidine
Inchi Key	DHGAOXXHXZSEGT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21FN2O2/c1-23-11-9-14(10-12-23)19(24)16-3-2-4-18(13-16)22-20(25)15-5-7-17(21)8-6-15/h2-8,13-14H,9-12H2,1H3,(H,22,25)
PubChem CID	9798021
ChEMBL	CHEMBL3617549
IUPHAR	N/A
BindingDB	50119543
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	87.0 nM	PMID26271587	BindingDB,ChEMBL
Emax	79.0 %	PMID26271587	ChEMBL
Ki	5.1 nM	PMID26271587	BindingDB,ChEMBL

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