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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymOrphanin FQ receptor
OP4
NOPr
NOP-r
NOP receptor
[ Show all ]
DiseaseInflammatory disease
Major depressive disorder
Central nervous system disease
Heart failure
Anxiety disorder
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhh, 5dhg, 4ea3
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhh.
BioLiPBL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameCHEMBL480619
Molecular formulaC21H31N3
IUPAC name1-[1-(1-methylcyclooctyl)piperidin-4-yl]benzimidazole
Molecular weight325.5
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP5.0
SynonymsBDBM50255137
1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole
Inchi KeyAGBAPGBKYWFEAF-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H31N3/c1-21(13-7-3-2-4-8-14-21)23-15-11-18(12-16-23)24-17-22-19-9-5-6-10-20(19)24/h5-6,9-10,17-18H,2-4,7-8,11-16H2,1H3
PubChem CID44570675
ChEMBLCHEMBL480619
IUPHARN/A
BindingDB50255137
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2.5 nMPMID19125610BindingDB,ChEMBL

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