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GPCR

NameG-protein coupled receptor 183
SpeciesHomo sapiens (Human)
GeneGPR183
SynonymEBI2 {ECO:0000303|PubMed:8383238}
lymphocyte-specific G protein-coupled receptor
hEBI2 {ECO:0000303|PubMed:22875855}
GPR183
G protein-coupled receptor 183
[ Show all ]
DiseaseN/A
Length361
Amino acid sequenceMDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProtP32249
Protein Data BankN/A
GPCR-HGmod modelP32249
3D structure modelThis predicted structure model is from GPCR-EXP P32249.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3259470
IUPHAR81
DrugBankN/A

Ligand

NameAC1MB8CK
Molecular formulaC20H21FN2O4S
IUPAC name(E)-3-(4-fluorophenyl)-1-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]prop-2-en-1-one
Molecular weight404.456
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.5
SynonymsCHEMBL3560467
SCHEMBL16598860
AKOS008518206
MLS-0472446.0001
(E)-3-(4-fluorophenyl)-1-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]prop-2-en-1-one
[ Show all ]
Inchi KeyFBYJWVQMIAADJN-NYYWCZLTSA-N
Inchi IDInChI=1S/C20H21FN2O4S/c1-27-18-7-9-19(10-8-18)28(25,26)23-14-12-22(13-15-23)20(24)11-4-16-2-5-17(21)6-3-16/h2-11H,12-15H2,1H3/b11-4+
PubChem CID2671117
ChEMBLCHEMBL3560467
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5012.1 nMPubChem BioAssay data setChEMBL

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