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GPCR

NameG-protein coupled receptor 183
SpeciesHomo sapiens (Human)
GeneGPR183
SynonymEBI2 {ECO:0000303|PubMed:8383238}
lymphocyte-specific G protein-coupled receptor
hEBI2 {ECO:0000303|PubMed:22875855}
GPR183
G protein-coupled receptor 183
[ Show all ]
DiseaseN/A
Length361
Amino acid sequenceMDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProtP32249
Protein Data BankN/A
GPCR-HGmod modelP32249
3D structure modelThis predicted structure model is from GPCR-EXP P32249.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3259470
IUPHAR81
DrugBankN/A

Ligand

NameCHEMBL3561495
Molecular formulaC21H19BrClF3N2O
IUPAC name(E)-3-(4-bromophenyl)-1-[4-[[4-chloro-2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]prop-2-en-1-one
Molecular weight487.745
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP5.3
SynonymsSCHEMBL16598544
SCHEMBL16598547
MLS-0472541.0001
Inchi KeyGBCIGVHHFDTHOQ-FPYGCLRLSA-N
Inchi IDInChI=1S/C21H19BrClF3N2O/c22-17-5-1-15(2-6-17)3-8-20(29)28-11-9-27(10-12-28)14-16-4-7-18(23)13-19(16)21(24,25)26/h1-8,13H,9-12,14H2/b8-3+
PubChem CID73330426
ChEMBLCHEMBL3561495
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC505.23 nMPubChem BioAssay data setChEMBL

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