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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	MLS003119183
Molecular formula	C19H18N2O4S
IUPAC name	2-(2-hydroxyethoxymethyl)-N-(4-phenoxyphenyl)-1,3-thiazole-4-carboxamide
Molecular weight	370.423
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.7
Synonyms	CHEMBL1875054 2-(2-hydroxyethoxymethyl)-N-(4-phenoxyphenyl)thiazole-4-carboxamide SMR001272718 BDBM97185 2-(2-hydroxyethoxymethyl)-N-(4-phenoxyphenyl)-1,3-thiazole-4-carboxamide cid_49786188 2-(2-hydroxyethyloxymethyl)-N-(4-phenoxyphenyl)-1,3-thiazole-4-carboxamide 2-(2-hydroxyethoxymethyl)-N-(4-phenoxyphenyl)-4-thiazolecarboxamide [ Show all ]
Inchi Key	GLBGMDYHCVIIJX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H18N2O4S/c22-10-11-24-12-18-21-17(13-26-18)19(23)20-14-6-8-16(9-7-14)25-15-4-2-1-3-5-15/h1-9,13,22H,10-12H2,(H,20,23)
PubChem CID	49786188
ChEMBL	CHEMBL1875054
IUPHAR	N/A
BindingDB	97185
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	5623.4 nM	PubChem BioAssay data set	ChEMBL

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