You can:
Name | Urotensin-2 receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Uts2r |
Synonym | UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 386 |
Amino acid sequence | MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL |
UniProt | P49684 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4921 |
IUPHAR | 365 |
DrugBank | N/A |
Name | CHEMBL3577305 |
---|---|
Molecular formula | C30H30N4O4 |
IUPAC name | (3S)-3-(4-aminobutyl)-1-[2-(4-hydroxyphenyl)ethyl]-5-naphthalen-2-yl-2-oxo-3,6-dihydropyrrolo[3,2-e][1,4]diazepine-7-carboxylic acid |
Molecular weight | 510.594 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 4 |
XlogP | 2.3 |
Synonyms | BDBM50089668 |
Inchi Key | LOTRUMFHUNAAMG-DEOSSOPVSA-N |
Inchi ID | InChI=1S/C30H30N4O4/c31-15-4-3-7-24-29(36)34(16-14-19-8-12-23(35)13-9-19)26-18-25(30(37)38)33-28(26)27(32-24)22-11-10-20-5-1-2-6-21(20)17-22/h1-2,5-6,8-13,17-18,24,33,35H,3-4,7,14-16,31H2,(H,37,38)/t24-/m0/s1 |
PubChem CID | 122177629 |
ChEMBL | CHEMBL3577305 |
IUPHAR | N/A |
BindingDB | 50089668 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 4.0 nM | PMID25984647 | ChEMBL |
EC50 | 4.0 nM | PMID25984647 | BindingDB |
EC50 | 4.677 nM | PMID25984647 | ChEMBL |
EC50 | 4.7 nM | PMID25984647 | BindingDB |
EC50 | 21.0 nM | PMID25984647 | BindingDB |
EC50 | 21.38 nM | PMID25984647 | ChEMBL |
EC50 | 21.4 nM | PMID25984647 | ChEMBL |
Emax | 51.0 % | PMID25984647 | ChEMBL |
Emax | 80.0 % | PMID25984647 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218