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GPCR

NamefMet-Leu-Phe receptor
SpeciesHomo sapiens (Human)
GeneFPR1
SynonymNFPR
N-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
[ Show all ]
DiseaseInflammatory disease
Peptic ulcer
Length350
Amino acid sequenceMETNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProtP21462
Protein Data BankN/A
GPCR-HGmod modelP21462
3D structure modelThis predicted structure model is from GPCR-EXP P21462.
BioLiPN/A
Therapeutic Target DatabaseT87831
ChEMBLCHEMBL3359
IUPHAR222
DrugBankBE0000995

Ligand

NameCHEMBL560780
Molecular formulaC21H20IN3O3
IUPAC nameN-(4-iodophenyl)-2-[5-[(3-methoxyphenyl)methyl]-3-methyl-6-oxopyridazin-1-yl]acetamide
Molecular weight489.313
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.2
SynonymsN-(4-Iodophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]-acetamide
BDBM50295515
Inchi KeyCRXUEUHJLRJWGE-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H20IN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
PubChem CID44233644
ChEMBLCHEMBL560780
IUPHARN/A
BindingDB50295515
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity90.0 %PMID19639995ChEMBL
EC5028.0 nMPMID19639995BindingDB
EC5032.0 nMPMID19639995BindingDB
EC502800.0 nMPMID19639995ChEMBL
EC503200.0 nMPMID19639995BindingDB,ChEMBL

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