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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	BRN 0628732
Molecular formula	C21H24N2O3
IUPAC name	1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Molecular weight	352.434
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.4
Synonyms	AC1MHLSZ 1-(3,4-Dimethoxybenzyl)-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole CHEMBL93513 2,3,4,9-Tetrahydro-1-((3,4-dimethoxyphenyl)methyl)-6-methoxy-1H-pyrido(3,4-b)indole (Dimethoxy-3',4' phenylmethyl)-1 methoxy-6 tetrahydro-2,3,4,9-1H-beta-carboline 1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole LS-133625 70265-32-6 (Dimethoxy-3',4' phenylmethyl)-1 methoxy-6 tetrahydro-2,3,4,9-1H-beta-carboline [French] 1H-Pyrido(3,4-b)indole, 2,3,4,9-tetrahydro-1-((3,4-dimethoxyphenyl)methyl)-6-methoxy- MCULE-3019816559 [ Show all ]
Inchi Key	CSBAVYNEVHLVAF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H24N2O3/c1-24-14-5-6-17-16(12-14)15-8-9-22-18(21(15)23-17)10-13-4-7-19(25-2)20(11-13)26-3/h4-7,11-12,18,22-23H,8-10H2,1-3H3
PubChem CID	3053662
ChEMBL	CHEMBL93513
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
-Log KB	8.48 -	PMID8709108	ChEMBL

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