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GPCR

NameLysophosphatidic acid receptor 1
SpeciesMus musculus (Mouse)
GeneLpar1
SynonymVZG-1 {ECO:0000303|PubMed:8922387, ECO:0000303|PubMed:9600933}
Rec1.3 {ECO:0000303|PubMed:9013780}
Lysophosphatidic acid receptor Edg-2 {ECO:0000303|PubMed:9600933}
lysophosphatidic acid receptor Edg-2
Lpar1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProtP61793
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621025
IUPHAR272
DrugBankN/A

Ligand

NameCHEMBL3621956
Molecular formulaC21H42NO6P
IUPAC name[(2R)-3-hydroxy-2-[[(Z)-octadec-9-enoyl]amino]propyl] dihydrogen phosphate
Molecular weight435.542
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP4.6
SynonymsN-{(1r)-2-hydroxy-1-[(phosphonooxy)methyl]ethyl}(9z)octadec-9-enamide
SCHEMBL13109923
Inchi KeyOTPODXRPJGBQEK-GDCKJWNLSA-N
Inchi IDInChI=1S/C21H42NO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)22-20(18-23)19-28-29(25,26)27/h9-10,20,23H,2-8,11-19H2,1H3,(H,22,24)(H2,25,26,27)/b10-9-/t20-/m1/s1
PubChem CID58787991
ChEMBLCHEMBL3621956
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC507.9 nMMedChemComm, (2015) 6:1:13ChEMBL

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