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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL68151
Molecular formulaC38H60N4O4+2
IUPAC name6-[dimethyl-[3-(3-oxo-1-propan-2-yloxy-1H-isoindol-2-yl)propyl]azaniumyl]hexyl-dimethyl-[3-(3-oxo-1-propan-2-yloxy-1H-isoindol-2-yl)propyl]azanium
Molecular weight636.922
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP5.5
SynonymsCHEMBL30376
BDBM50408909
Hexamethylenebis[[3-(3-isopropoxy-1-oxoisoindoline-2-yl)propyl]dimethylaminium]
Inchi KeyCSNFZDMXWPEAMV-UHFFFAOYSA-N
Inchi IDInChI=1S/C38H60N4O4/c1-29(2)45-37-33-21-13-11-19-31(33)35(43)39(37)23-17-27-41(5,6)25-15-9-10-16-26-42(7,8)28-18-24-40-36(44)32-20-12-14-22-34(32)38(40)46-30(3)4/h11-14,19-22,29-30,37-38H,9-10,15-18,23-28H2,1-8H3/q+2
PubChem CID10629136
ChEMBLCHEMBL30376
IUPHARN/A
BindingDB50408909
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC501584.89 nMPMID12672239, PMID10841794BindingDB,ChEMBL

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