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GLASS

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GPCR

Name	G-protein coupled bile acid receptor 1
Species	Homo sapiens (Human)
Gene	GPBAR1
Synonym	G-protein coupled receptor GPCR19 TGR5 BG37 G protein-coupled bile acid receptor 1 membrane-type receptor for bile acids M-BAR hGPCR19 hBG37 GPCR19 GPBAR1 GPBA receptor GPR131 [ Show all ]
Disease	Type 2 diabetes Metabolic disorders
Length	330
Amino acid sequence	MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
UniProt	Q8TDU6
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDU6
3D structure model	This predicted structure model is from GPCR-EXP Q8TDU6.
BioLiP	N/A
Therapeutic Target Database	T86273
ChEMBL	CHEMBL5409
IUPHAR	37
DrugBank	BE0005788

Ligand

Name	CHEMBL3132966
Molecular formula	C20H19ClN4O2
IUPAC name	N-(4-chlorophenyl)-5-cyclopropyl-3-(3-methoxyphenyl)-N-methyltriazole-4-carboxamide
Molecular weight	382.848
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.9
Synonyms	N-Methyl-N-(4-chlorophenyl)-1-(3-methoxyphenyl)-4-cyclopropyl-1H-1,2,3-triazole-5-carboxamide
Inchi Key	AGKYBJAEPMUCHJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19ClN4O2/c1-24(15-10-8-14(21)9-11-15)20(26)19-18(13-6-7-13)22-23-25(19)16-4-3-5-17(12-16)27-2/h3-5,8-13H,6-7H2,1-2H3
PubChem CID	76314787
ChEMBL	CHEMBL3132966
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.9 nM	MedChemComm, (2013) 4:1:205	ChEMBL

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