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GPCR

NameAlpha-2B adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra2b
SynonymADRA2L1
alpha2B-adrenoceptor
alpha2B
alpha2-C2
alpha-2BAR
[ Show all ]
DiseaseN/A for non-human GPCRs
Length453
Amino acid sequenceMSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProtP19328
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL266
IUPHAR26
DrugBankN/A

Ligand

NameCHEMBL304132
Molecular formulaC32H36N4O4
IUPAC name2-(4-methylphenyl)-1,3-dioxo-N-[3-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]propyl]isoindole-5-carboxamide
Molecular weight540.664
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.9
SynonymsSCHEMBL6586620
BDBM50088405
N-[3-[4-(2-Isopropoxyphenyl)piperazino]propyl]-2-(4-methylphenyl)-1,3-dioxoisoindoline-5-carboxamide
1,3-Dioxo-2-p-tolyl-2,3-dihydro-1H-isoindole-5-carboxylic acid {3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propyl}-amide
Inchi KeyCSXUKDQJFRHATO-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H36N4O4/c1-22(2)40-29-8-5-4-7-28(29)35-19-17-34(18-20-35)16-6-15-33-30(37)24-11-14-26-27(21-24)32(39)36(31(26)38)25-12-9-23(3)10-13-25/h4-5,7-14,21-22H,6,15-20H2,1-3H3,(H,33,37)
PubChem CID10530491
ChEMBLCHEMBL304132
IUPHARN/A
BindingDB50088405
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition66.0 %PMID10841797ChEMBL

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