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GPCR

NameMu-type opioid receptor
SpeciesHomo sapiens (Human)
GeneOPRM1
SynonymhMOP
M-OR-1
MOP
opioid receptor, mu 1
opioid receptor
[ Show all ]
DiseaseDiarrhea
Inflammatory disease
Pain
Major depressive disorder
Migraine
[ Show all ]
Length400
Amino acid sequenceMDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProtP35372
Protein Data BankN/A
GPCR-HGmod modelP35372
3D structure modelThis predicted structure model is from GPCR-EXP P35372.
BioLiPN/A
Therapeutic Target DatabaseT47768
ChEMBLCHEMBL233
IUPHAR319
DrugBankBE0000770

Ligand

NameCHEMBL369786
Molecular formulaC25H33N3O2
IUPAC name3-[1-[4-methyl-3-(2-methylphenoxy)pentyl]piperidin-4-yl]-1H-benzimidazol-2-one
Molecular weight407.558
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.8
Synonyms1-[1-(4-Methyl-3-o-tolyloxy-pentyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one
BDBM50159916
Inchi KeyAGLOLGURRWOWKK-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H33N3O2/c1-18(2)23(30-24-11-7-4-8-19(24)3)14-17-27-15-12-20(13-16-27)28-22-10-6-5-9-21(22)26-25(28)29/h4-11,18,20,23H,12-17H2,1-3H3,(H,26,29)
PubChem CID44391079
ChEMBLCHEMBL369786
IUPHARN/A
BindingDB50159916
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki21.0 nMPMID15664818BindingDB,ChEMBL

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