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Name | Orexin receptor type 2 |
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Species | Rattus norvegicus (Rat) |
Gene | Hcrtr2 |
Synonym | hypocretin receptor 2 Hypocretin receptor type 2 hypocretin (orexin) receptor 2 orexin receptor type 2 Ox-2-R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 460 |
Amino acid sequence | MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV |
UniProt | P56719 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1275216 |
IUPHAR | 322 |
DrugBank | N/A |
Name | CHEMBL3586433 |
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Molecular formula | C21H22FN7O |
IUPAC name | [(3aR,6aS)-2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[3-fluoro-2-(triazol-2-yl)phenyl]methanone |
Molecular weight | 407.453 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 2.8 |
Synonyms | BDBM50092812 ((3aR,6aS)-5-(4,6-Dimethylpyrimidine-2-yl)octahydropyrrolo[3,4-c]pyrrole-2-yl)(2-(2H-1,2,3-triazole-2-yl)-3-fluorophenyl)methanone |
Inchi Key | RQCIXSIWGGVIAE-IYBDPMFKSA-N |
Inchi ID | InChI=1S/C21H22FN7O/c1-13-8-14(2)26-21(25-13)28-11-15-9-27(10-16(15)12-28)20(30)17-4-3-5-18(22)19(17)29-23-6-7-24-29/h3-8,15-16H,9-12H2,1-2H3/t15-,16+ |
PubChem CID | 122180337 |
ChEMBL | CHEMBL3586433 |
IUPHAR | N/A |
BindingDB | 50092812 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 10.0 nM | PMID26087021 | ChEMBL |
Ki | 10.0 nM | PMID26087021 | BindingDB |
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