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GPCR

NameG-protein coupled receptor 183
SpeciesHomo sapiens (Human)
GeneGPR183
SynonymEBI2 {ECO:0000303|PubMed:8383238}
lymphocyte-specific G protein-coupled receptor
hEBI2 {ECO:0000303|PubMed:22875855}
GPR183
G protein-coupled receptor 183
[ Show all ]
DiseaseN/A
Length361
Amino acid sequenceMDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProtP32249
Protein Data BankN/A
GPCR-HGmod modelP32249
3D structure modelThis predicted structure model is from GPCR-EXP P32249.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3259470
IUPHAR81
DrugBankN/A

Ligand

NameCHEMBL3561719
Molecular formulaC23H27BrN2O
IUPAC name(E)-3-(4-bromophenyl)-1-[4-[(4-propan-2-ylphenyl)methyl]piperazin-1-yl]prop-2-en-1-one
Molecular weight427.386
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP4.9
SynonymsSCHEMBL16598703
MLS-0472530.0001
SCHEMBL16598699
Inchi KeyUYMYWXIKQXTQKA-KPKJPENVSA-N
Inchi IDInChI=1S/C23H27BrN2O/c1-18(2)21-8-3-20(4-9-21)17-25-13-15-26(16-14-25)23(27)12-7-19-5-10-22(24)11-6-19/h3-12,18H,13-17H2,1-2H3/b12-7+
PubChem CID73330418
ChEMBLCHEMBL3561719
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC505.92 nMPubChem BioAssay data setChEMBL

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