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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL350851
Molecular formula	C26H30N4O5S
IUPAC name	methyl 2-butyl-3-[[4-[2-(cyclopropanecarbonylsulfamoylamino)phenyl]phenyl]methyl]imidazole-4-carboxylate
Molecular weight	510.609
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.6
Synonyms	BDBM50282417
Inchi Key	CUKWLCNLRLXBHS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H30N4O5S/c1-3-4-9-24-27-16-23(26(32)35-2)30(24)17-18-10-12-19(13-11-18)21-7-5-6-8-22(21)28-36(33,34)29-25(31)20-14-15-20/h5-8,10-13,16,20,28H,3-4,9,14-15,17H2,1-2H3,(H,29,31)
PubChem CID	44376747
ChEMBL	CHEMBL350851
IUPHAR	N/A
BindingDB	50282417
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	10000.0 nM	, Bioorg. Med. Chem. Lett., (1994) 4:1:69	BindingDB,ChEMBL

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