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GPCR

NameG-protein coupled receptor 183
SpeciesHomo sapiens (Human)
GeneGPR183
SynonymEBI2 {ECO:0000303|PubMed:8383238}
lymphocyte-specific G protein-coupled receptor
hEBI2 {ECO:0000303|PubMed:22875855}
GPR183
G protein-coupled receptor 183
[ Show all ]
DiseaseN/A
Length361
Amino acid sequenceMDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProtP32249
Protein Data BankN/A
GPCR-HGmod modelP32249
3D structure modelThis predicted structure model is from GPCR-EXP P32249.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3259470
IUPHAR81
DrugBankN/A

Ligand

NameCHEMBL3561399
Molecular formulaC19H18Br2N2O3S
IUPAC name(E)-3-(4-bromophenyl)-1-[4-(4-bromophenyl)sulfonylpiperazin-1-yl]prop-2-en-1-one
Molecular weight514.232
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.8
SynonymsMLS-0472508.0001
SCHEMBL16599366
SCHEMBL16599367
Inchi KeyXCMSDJXXCVZPIC-XCVCLJGOSA-N
Inchi IDInChI=1S/C19H18Br2N2O3S/c20-16-4-1-15(2-5-16)3-10-19(24)22-11-13-23(14-12-22)27(25,26)18-8-6-17(21)7-9-18/h1-10H,11-14H2/b10-3+
PubChem CID71295907
ChEMBLCHEMBL3561399
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC501.66 nMPubChem BioAssay data setChEMBL

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