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Name | Metabotropic glutamate receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | GRM4 |
Synonym | mGluR4 mGlu4 receptor GPRC1D glutamate receptor |
Disease | Anxiety disorder Neurological disease |
Length | 912 |
Amino acid sequence | MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI |
UniProt | Q14833 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T99402 |
ChEMBL | CHEMBL2736 |
IUPHAR | 292 |
DrugBank | BE0000833 |
Name | CHEMBL3808861 |
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Molecular formula | C18H15F2N3O3S2 |
IUPAC name | N-[5-[(2,6-difluorophenyl)methylsulfonyl]-4-ethyl-1,3-thiazol-2-yl]pyridine-2-carboxamide |
Molecular weight | 423.453 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 1 |
XlogP | 3.5 |
Synonyms | US9192603, 33 BDBM192860 SCHEMBL12182219 |
Inchi Key | BSRXAWATLADJTQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H15F2N3O3S2/c1-2-14-17(28(25,26)10-11-12(19)6-5-7-13(11)20)27-18(22-14)23-16(24)15-8-3-4-9-21-15/h3-9H,2,10H2,1H3,(H,22,23,24) |
PubChem CID | 54670499 |
ChEMBL | CHEMBL3808861 |
IUPHAR | N/A |
BindingDB | 192860 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
%max | 109.0 % | PMID27234146 | ChEMBL |
EC50 | 139.0 nM | , None | BindingDB,ChEMBL |
EC50 | 150.0 nM | PMID27234146 | BindingDB,ChEMBL |
EC50 | 151.0 nM | PMID27234146 | BindingDB |
EC50 | 151.36 nM | PMID27234146 | ChEMBL |
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