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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL127416
Molecular formulaC28H50NO3S+
IUPAC name(4-tetradecyloxolan-2-yl)methyl 6-(1,3-thiazol-3-ium-3-yl)hexanoate
Molecular weight480.772
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP9.6
Synonyms3-[6-[[Tetrahydro-4-tetradecylfuran]-2-ylmethoxy]-6-oxohexyl]thiazolium
CHEMBL1180476
BDBM50011070
Toluene-4-sulfonate3-[5-(4-tetradecyl-tetrahydro-furan-2-ylmethoxycarbonyl)-pentyl]-thiazol-3-ium;Toluene-4-sulfonate
Inchi KeyANXWNDVKXKVIJB-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H50NO3S/c1-2-3-4-5-6-7-8-9-10-11-12-14-17-26-22-27(31-23-26)24-32-28(30)18-15-13-16-19-29-20-21-33-25-29/h20-21,25-27H,2-19,22-24H2,1H3/q+1
PubChem CID14785876
ChEMBLN/A
IUPHARN/A
BindingDB50011070
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<50000.0 nMPMID1992139BindingDB

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