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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	BDBM50004634
Molecular formula	C35H29N7O3
IUPAC name	ethyl 4-(4-cyanophenyl)-2-methyl-6-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-3-(pyridin-2-ylcarbamoyl)-3,4-dihydropyridine-5-carboxylate
Molecular weight	595.663
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.1
Synonyms	4-(4-Cyano-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester
Inchi Key	BBNUOCDJMUXUGK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C35H29N7O3/c1-4-45-35(44)32-31(24-10-8-23(19-36)9-11-24)30(34(43)41-29-7-5-6-17-38-29)21(2)39-33(32)25-12-14-26(15-13-25)42-22(3)40-27-20-37-18-16-28(27)42/h5-18,20,30-31H,4H2,1-3H3,(H,38,41,43)
PubChem CID	53673528
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50004634
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	25.0 nM	PMID1507200	BindingDB

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