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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279073
Molecular formula	C15H17N5O2
IUPAC name	N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-4-methyl-1H-pyrrole-2-carboxamide
Molecular weight	299.334
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.4
Synonyms	CHEMBL3986303 BDBM211010 US9247759, 4-45
Inchi Key	CQGTZQSZWGNSOJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H17N5O2/c1-9-4-14(16-5-9)15(21)18-12-6-17-20(7-12)8-13-10(2)19-22-11(13)3/h4-7,16H,8H2,1-3H3,(H,18,21)
PubChem CID	57422284
ChEMBL	CHEMBL3986303
IUPHAR	N/A
BindingDB	211010
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	720.0 nM	N/A	BindingDB
IC50	720.0 nM	None	ChEMBL

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