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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1279617
Molecular formulaC22H25N5O4
IUPAC name3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-5,5-dimethyl-1-(2-phenoxyethyl)imidazolidine-2,4-dione
Molecular weight423.473
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.3
Synonyms3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethyl-1-(2-phenoxyethyl)imidazolidine-2,4-dione
CHEMBL3961048
US9247759, 12-27
BDBM211376
DXVLDEYHGXZPNM-UHFFFAOYSA-N
Inchi KeyDXVLDEYHGXZPNM-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H25N5O4/c1-15-19(16(2)31-24-15)14-25-13-17(12-23-25)27-20(28)22(3,4)26(21(27)29)10-11-30-18-8-6-5-7-9-18/h5-9,12-13H,10-11,14H2,1-4H3
PubChem CID53374079
ChEMBLCHEMBL3961048
IUPHARN/A
BindingDB211376
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50350.0 nMN/ABindingDB
IC50350.0 nMNoneChEMBL

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