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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1279302
Molecular formulaC20H20N6O4
IUPAC name1-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-3-(2-phenylethyl)-1,3,5-triazinane-2,4,6-trione
Molecular weight408.418
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP1.9
Synonyms1-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1h-pyrazol-4-yl)-3-phenethyl-1,3,5-triazinane-2,4,6-trione
CHEMBL3921539
US9247759, 9-8
BDBM211251
HHNBWUXXSNQVLG-UHFFFAOYSA-N
Inchi KeyHHNBWUXXSNQVLG-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H20N6O4/c1-13-17(14(2)30-23-13)12-24-11-16(10-21-24)26-19(28)22-18(27)25(20(26)29)9-8-15-6-4-3-5-7-15/h3-7,10-11H,8-9,12H2,1-2H3,(H,22,27,28)
PubChem CID57422422
ChEMBLCHEMBL3921539
IUPHARN/A
BindingDB211251
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC503030.0 nMNoneChEMBL
IC503030.0 nMN/ABindingDB

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