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Name | Taste receptor type 2 member 14 |
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Species | Homo sapiens (Human) |
Gene | TAS2R14 |
Synonym | T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1 |
Disease | N/A |
Length | 317 |
Amino acid sequence | MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS |
UniProt | Q9NYV8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9NYV8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9NYV8. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3309105 |
IUPHAR | N/A |
DrugBank | N/A |
Name | AC1NSIFU |
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Molecular formula | C18H25N5O3S |
IUPAC name | 7-ethyl-1,3-dimethyl-5-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]sulfanylpyrimido[4,5-d]pyrimidine-2,4-dione |
Molecular weight | 391.49 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 1.9 |
Synonyms | MolPort-003-040-968 CHEMBL1499181 SCHEMBL1279938 7-ethyl-1,3-dimethyl-5-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]sulfanylpyrimido[4,5-d]pyrimidine-2,4-dione MCULE-7867844771 [ Show all ] |
Inchi Key | IKSHHOBCJKJKOG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H25N5O3S/c1-5-12-19-15-14(17(25)22(4)18(26)21(15)3)16(20-12)27-10-13(24)23-8-6-11(2)7-9-23/h11H,5-10H2,1-4H3 |
PubChem CID | 5310181 |
ChEMBL | CHEMBL1499181 |
IUPHAR | N/A |
BindingDB | 211239 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 721.0 nM | None | ChEMBL |
IC50 | 721.0 nM | N/A | BindingDB |
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