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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	AC1NT3IW
Molecular formula	C25H30BrNO6S
IUPAC name	ethyl 4-[[(3-bromophenyl)methyl-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]methyl]cyclohexane-1-carboxylate
Molecular weight	552.48
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.7
Synonyms	ethyl 4-[[(3-bromophenyl)methyl-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]methyl]cyclohexane-1-carboxylate US9247759, 5-116 MolPort-007-929-176 SR-01000582810-1 ethyl 4-{[(3-bromobenzyl)(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]methyl}cyclohexanecarboxylate ZINC98009716 AKOS002116364 SCHEMBL1615828 CHEMBL3900023 UNM000000887501 EU-0063632 BDBM211170 SR-01000582810 [ Show all ]
Inchi Key	NPEHVZUAWFRIBL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H30BrNO6S/c1-2-31-25(28)20-8-6-18(7-9-20)16-27(17-19-4-3-5-21(26)14-19)34(29,30)22-10-11-23-24(15-22)33-13-12-32-23/h3-5,10-11,14-15,18,20H,2,6-9,12-13,16-17H2,1H3
PubChem CID	5323300
ChEMBL	CHEMBL3900023
IUPHAR	N/A
BindingDB	211170
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2567.0 nM	None	ChEMBL
IC50	2567.0 nM	N/A	BindingDB

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