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GLASS

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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279599
Molecular formula	C20H23FN2O4S
IUPAC name	4-[[(4-fluorophenyl)methyl-pyridin-3-ylsulfonylamino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	406.472
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	2.6
Synonyms	US9247759, 5-52 CHEMBL3911496 BDBM211128
Inchi Key	OVCYEPFOSFYFSL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H23FN2O4S/c21-18-9-5-16(6-10-18)14-23(28(26,27)19-2-1-11-22-12-19)13-15-3-7-17(8-4-15)20(24)25/h1-2,5-6,9-12,15,17H,3-4,7-8,13-14H2,(H,24,25)
PubChem CID	57944918
ChEMBL	CHEMBL3911496
IUPHAR	N/A
BindingDB	211128
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8434.0 nM	N/A	BindingDB
IC50	8434.0 nM	None	ChEMBL

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