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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278916
Molecular formula	C22H21NO6S
IUPAC name	4-[[(4-hydroxyphenyl)sulfonyl-[(2-methoxyphenyl)methyl]amino]methyl]benzoic acid
Molecular weight	427.471
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.2
Synonyms	CHEMBL3929937 US9247759, 5-42 BDBM211118 SAOZWYAIVLBQRF-UHFFFAOYSA-N 4-((4-hydroxy-N-(2-methoxybenzyl)phenylsulfonamido)methyl)-benzoic acid
Inchi Key	SAOZWYAIVLBQRF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H21NO6S/c1-29-21-5-3-2-4-18(21)15-23(14-16-6-8-17(9-7-16)22(25)26)30(27,28)20-12-10-19(24)11-13-20/h2-13,24H,14-15H2,1H3,(H,25,26)
PubChem CID	25207289
ChEMBL	CHEMBL3929937
IUPHAR	N/A
BindingDB	211118
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2560.0 nM	None	ChEMBL
IC50	2560.0 nM	N/A	BindingDB

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