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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3715726
Molecular formulaC28H23ClN4O5S2
IUPAC name6-[4-[[2-[3-(3-chlorophenyl)oxolan-3-yl]-1,3-thiazol-4-yl]methoxy]-6-methoxy-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Molecular weight595.085
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP6.1
SynonymsUS9688695, 165
BDBM176132
SCHEMBL15348867
Inchi KeyADYNYJCSXKIJKJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H23ClN4O5S2/c1-34-19-9-22(20-11-24(38-23(20)10-19)21-12-33-26(31-21)40-27(32-33)35-2)37-13-18-14-39-25(30-18)28(6-7-36-15-28)16-4-3-5-17(29)8-16/h3-5,8-12,14H,6-7,13,15H2,1-2H3
PubChem CID89872882
ChEMBLCHEMBL3715726
IUPHARN/A
BindingDB176132
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC501.1 nMNoneChEMBL
EC501.1 nMN/ABindingDB

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