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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3717407
Molecular formulaC27H19F3N4O4S
IUPAC name4-[[6-methoxy-2-(6-methylimidazo[1,2-b]pyridazin-2-yl)-1-benzofuran-4-yl]oxymethyl]-2-[4-(trifluoromethoxy)phenyl]-1,3-thiazole
Molecular weight552.528
Hydrogen bond acceptor11
Hydrogen bond donor0
XlogP6.2
SynonymsBDBM176177
SCHEMBL15349080
US9688695, 210
Inchi KeyAJSPEUMSCZMVPC-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H19F3N4O4S/c1-15-3-8-25-32-21(12-34(25)33-15)24-11-20-22(9-19(35-2)10-23(20)37-24)36-13-17-14-39-26(31-17)16-4-6-18(7-5-16)38-27(28,29)30/h3-12,14H,13H2,1-2H3
PubChem CID89873055
ChEMBLCHEMBL3717407
IUPHARN/A
BindingDB176177
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC500.86 nMN/ABindingDB
EC500.86 nM, NoneBindingDB,ChEMBL

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