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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

Name2-methoxy-6-(6-methoxy-4-((6-(4-methoxytetrahydro-2H-pyran-4-yl)pyridin-2-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Molecular formulaC26H26N4O6S
IUPAC name2-methoxy-6-[6-methoxy-4-[[6-(4-methoxyoxan-4-yl)pyridin-2-yl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight522.576
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP3.5
SynonymsBDBM286492
SCHEMBL15349802
US9518064, Example 111
AOERGMCIEVXOCP-UHFFFAOYSA-N
CHEMBL3716902
Inchi KeyAOERGMCIEVXOCP-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H26N4O6S/c1-31-17-11-20(35-15-16-5-4-6-23(27-16)26(33-3)7-9-34-10-8-26)18-13-22(36-21(18)12-17)19-14-30-24(28-19)37-25(29-30)32-2/h4-6,11-14H,7-10,15H2,1-3H3
PubChem CID72192122
ChEMBLCHEMBL3716902
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC500.23 nMNoneChEMBL

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