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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3731418
Molecular formulaC21H16FN3O2S
IUPAC name2-(1-fluoroethyl)-6-(6-phenylmethoxy-1-benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight393.436
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP5.0
SynonymsSCHEMBL16708163
Inchi KeyAPCVABPTTCXMIW-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H16FN3O2S/c1-13(22)20-24-25-11-17(23-21(25)28-20)19-9-15-7-8-16(10-18(15)27-19)26-12-14-5-3-2-4-6-14/h2-11,13H,12H2,1H3
PubChem CID118068584
ChEMBLCHEMBL3731418
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50318.1 nMNoneChEMBL

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