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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3731418
Molecular formula	C21H16FN3O2S
IUPAC name	2-(1-fluoroethyl)-6-(6-phenylmethoxy-1-benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight	393.436
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	5.0
Synonyms	SCHEMBL16708163
Inchi Key	APCVABPTTCXMIW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H16FN3O2S/c1-13(22)20-24-25-11-17(23-21(25)28-20)19-9-15-7-8-16(10-18(15)27-19)26-12-14-5-3-2-4-6-14/h2-11,13H,12H2,1H3
PubChem CID	118068584
ChEMBL	CHEMBL3731418
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	318.1 nM	None	ChEMBL

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