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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3732006
Molecular formulaC20H16N4O3S2
IUPAC name6-methoxy-2-(2-methylsulfanylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-4-phenylmethoxy-1,3-benzoxazole
Molecular weight424.493
Hydrogen bond acceptor8
Hydrogen bond donor0
XlogP4.7
SynonymsAYIWNIZQFUMBCE-UHFFFAOYSA-N
SCHEMBL15349845
4-(Benzyloxy)-6-methoxy-2-(2-(methylthio)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzo[d]oxazole
Inchi KeyAYIWNIZQFUMBCE-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H16N4O3S2/c1-25-13-8-15(26-11-12-6-4-3-5-7-12)17-16(9-13)27-18(22-17)14-10-24-19(21-14)29-20(23-24)28-2/h3-10H,11H2,1-2H3
PubChem CID72201420
ChEMBLCHEMBL3732006
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5010.56 nMNoneChEMBL

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