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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3716844
Molecular formula	C30H27N5O6S2
IUPAC name	[4-hydroxy-4-[4-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]piperidin-1-yl]-phenylmethanone
Molecular weight	617.695
Hydrogen bond acceptor	11
Hydrogen bond donor	1
XlogP	4.4
Synonyms	(4-Hydroxy-4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)thiazol-2-yl)piperidin-1-yl)(phenyl)methanone BDBM176097 SCHEMBL15357153 US9688695, 130 BACOJTRRFFVSSS-UHFFFAOYSA-N
Inchi Key	BACOJTRRFFVSSS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H27N5O6S2/c1-38-20-12-23(21-14-25(41-24(21)13-20)22-15-35-28(32-22)43-29(33-35)39-2)40-16-19-17-42-27(31-19)30(37)8-10-34(11-9-30)26(36)18-6-4-3-5-7-18/h3-7,12-15,17,37H,8-11,16H2,1-2H3
PubChem CID	72192427
ChEMBL	CHEMBL3716844
IUPHAR	N/A
BindingDB	176097
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.4 nM	N/A	BindingDB
EC50	0.4 nM	None	ChEMBL

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