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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3715995
Molecular formulaC24H22F3N5O6S3
IUPAC name2-methoxy-6-[6-methoxy-4-[[2-[1-(trifluoromethylsulfonyl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight629.644
Hydrogen bond acceptor15
Hydrogen bond donor0
XlogP4.8
SynonymsUS9688695, 114
BDBM176081
SCHEMBL15357167
Inchi KeyBDZNBNNJQRTJAR-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H22F3N5O6S3/c1-35-15-7-18(16-9-20(38-19(16)8-15)17-10-32-22(29-17)40-23(30-32)36-2)37-11-14-12-39-21(28-14)13-3-5-31(6-4-13)41(33,34)24(25,26)27/h7-10,12-13H,3-6,11H2,1-2H3
PubChem CID72191506
ChEMBLCHEMBL3715995
IUPHARN/A
BindingDB176081
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC500.49 nMN/ABindingDB
EC500.49 nM, NoneBindingDB,ChEMBL

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