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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3718074
Molecular formula	C31H29N5O5S2
IUPAC name	N-(cyclopropylmethyl)-N-ethyl-4-[4-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]benzamide
Molecular weight	615.723
Hydrogen bond acceptor	10
Hydrogen bond donor	0
XlogP	6.0
Synonyms	US9688695, 312 BDBM176279 SCHEMBL16603385
Inchi Key	BFHJWCFMRAWQFO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H29N5O5S2/c1-4-35(14-18-5-6-18)29(37)20-9-7-19(8-10-20)28-32-21(17-42-28)16-40-25-11-22(38-2)12-26-23(25)13-27(41-26)24-15-36-30(33-24)43-31(34-36)39-3/h7-13,15,17-18H,4-6,14,16H2,1-3H3
PubChem CID	117981594
ChEMBL	CHEMBL3718074
IUPHAR	N/A
BindingDB	176279
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.77 nM	N/A	BindingDB
EC50	0.77 nM	, None	BindingDB,ChEMBL

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