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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3717746
Molecular formulaC24H19N5O4S2
IUPAC name2-methoxy-6-[6-methoxy-4-[[2-(6-methylpyridin-3-yl)-1,3-thiazol-4-yl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight505.567
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP4.7
SynonymsBDBM176041
SCHEMBL15356733
US9688695, 74
Inchi KeyBJIQNZYXWYUXEW-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H19N5O4S2/c1-13-4-5-14(9-25-13)22-26-15(12-34-22)11-32-19-6-16(30-2)7-20-17(19)8-21(33-20)18-10-29-23(27-18)35-24(28-29)31-3/h4-10,12H,11H2,1-3H3
PubChem CID89878888
ChEMBLCHEMBL3717746
IUPHARN/A
BindingDB176041
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC500.56 nMN/ABindingDB
EC500.56 nM, NoneBindingDB,ChEMBL
EC500.96 nMN/ABindingDB
IC500.96 nMNoneChEMBL

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