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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3717427
Molecular formula	C26H27N5O4S
IUPAC name	(2S,6R)-4-[4-[[6-methoxy-2-(6-methylimidazo[1,2-b]pyridazin-2-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]-2,6-dimethylmorpholine
Molecular weight	505.593
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	4.3
Synonyms	BDBM176183 SCHEMBL16603287 US9688695, 216
Inchi Key	BRJLWOZTWLSNMI-CALCHBBNSA-N
Inchi ID	InChI=1S/C26H27N5O4S/c1-15-5-6-25-28-21(12-31(25)29-15)24-9-20-22(7-19(32-4)8-23(20)35-24)33-13-18-14-36-26(27-18)30-10-16(2)34-17(3)11-30/h5-9,12,14,16-17H,10-11,13H2,1-4H3/t16-,17+
PubChem CID	117981496
ChEMBL	CHEMBL3717427
IUPHAR	N/A
BindingDB	176183
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.99 nM	, None	BindingDB,ChEMBL
EC50	0.99 nM	N/A	BindingDB

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