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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3717427
Molecular formulaC26H27N5O4S
IUPAC name(2S,6R)-4-[4-[[6-methoxy-2-(6-methylimidazo[1,2-b]pyridazin-2-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]-2,6-dimethylmorpholine
Molecular weight505.593
Hydrogen bond acceptor9
Hydrogen bond donor0
XlogP4.3
SynonymsBDBM176183
SCHEMBL16603287
US9688695, 216
Inchi KeyBRJLWOZTWLSNMI-CALCHBBNSA-N
Inchi IDInChI=1S/C26H27N5O4S/c1-15-5-6-25-28-21(12-31(25)29-15)24-9-20-22(7-19(32-4)8-23(20)35-24)33-13-18-14-36-26(27-18)30-10-16(2)34-17(3)11-30/h5-9,12,14,16-17H,10-11,13H2,1-4H3/t16-,17+
PubChem CID117981496
ChEMBLCHEMBL3717427
IUPHARN/A
BindingDB176183
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC500.99 nM, NoneBindingDB,ChEMBL
EC500.99 nMN/ABindingDB

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