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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3715042
Molecular formulaC26H28N6O4S
IUPAC name2-[4-[4-[[6-methoxy-2-(6-methylimidazo[1,2-b]pyridazin-2-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]piperazin-1-yl]ethanol
Molecular weight520.608
Hydrogen bond acceptor10
Hydrogen bond donor1
XlogP2.9
SynonymsBDBM176210
SCHEMBL16603317
US9688695, 243
Inchi KeyBZUNUHLCZQADSW-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H28N6O4S/c1-17-3-4-25-28-21(14-32(25)29-17)24-13-20-22(11-19(34-2)12-23(20)36-24)35-15-18-16-37-26(27-18)31-7-5-30(6-8-31)9-10-33/h3-4,11-14,16,33H,5-10,15H2,1-2H3
PubChem CID117981526
ChEMBLCHEMBL3715042
IUPHARN/A
BindingDB176210
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<3000.0 nMN/ABindingDB
EC5032.0 nM, NoneBindingDB,ChEMBL
EC5032.0 nMN/ABindingDB
IC50<3000.0 nMNoneChEMBL

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