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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3717023
Molecular formula	C24H21F3N4O4S2
IUPAC name	2-methoxy-6-[6-methoxy-4-[[2-(1,4,4-trifluorocyclohexyl)-1,3-thiazol-4-yl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight	550.571
Hydrogen bond acceptor	12
Hydrogen bond donor	0
XlogP	5.7
Synonyms	SCHEMBL15349241 2-Methoxy-6-(6-methoxy-4-((2-(1,4,4-trifluorocyclohexyl)thiazol-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole US9688695, 136 BDBM176103 CIDNRJHWKLRZDQ-UHFFFAOYSA-N
Inchi Key	CIDNRJHWKLRZDQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H21F3N4O4S2/c1-32-14-7-17(34-11-13-12-36-20(28-13)23(25)3-5-24(26,27)6-4-23)15-9-19(35-18(15)8-14)16-10-31-21(29-16)37-22(30-31)33-2/h7-10,12H,3-6,11H2,1-2H3
PubChem CID	72192724
ChEMBL	CHEMBL3717023
IUPHAR	N/A
BindingDB	176103
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.2 nM	None	ChEMBL
EC50	1.2 nM	N/A	BindingDB

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