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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3717023
Molecular formulaC24H21F3N4O4S2
IUPAC name2-methoxy-6-[6-methoxy-4-[[2-(1,4,4-trifluorocyclohexyl)-1,3-thiazol-4-yl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight550.571
Hydrogen bond acceptor12
Hydrogen bond donor0
XlogP5.7
SynonymsUS9688695, 136
BDBM176103
CIDNRJHWKLRZDQ-UHFFFAOYSA-N
SCHEMBL15349241
2-Methoxy-6-(6-methoxy-4-((2-(1,4,4-trifluorocyclohexyl)thiazol-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
Inchi KeyCIDNRJHWKLRZDQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H21F3N4O4S2/c1-32-14-7-17(34-11-13-12-36-20(28-13)23(25)3-5-24(26,27)6-4-23)15-9-19(35-18(15)8-14)16-10-31-21(29-16)37-22(30-31)33-2/h7-10,12H,3-6,11H2,1-2H3
PubChem CID72192724
ChEMBLCHEMBL3717023
IUPHARN/A
BindingDB176103
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC501.2 nMNoneChEMBL
EC501.2 nMN/ABindingDB

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