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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3729522
Molecular formulaC22H25N3O4S
IUPAC nameethyl 6-[[2-(2-ethylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-7-yl]oxy]hexanoate
Molecular weight427.519
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP5.0
SynonymsSCHEMBL16710636
Inchi KeyCUAVFYFSPYDLOY-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H25N3O4S/c1-3-19-24-25-14-16(23-22(25)30-19)18-13-15-9-8-10-17(21(15)29-18)28-12-7-5-6-11-20(26)27-4-2/h8-10,13-14H,3-7,11-12H2,1-2H3
PubChem CID118070666
ChEMBLCHEMBL3729522
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501467.0 nMNoneChEMBL

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