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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3729522
Molecular formula	C22H25N3O4S
IUPAC name	ethyl 6-[[2-(2-ethylimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-7-yl]oxy]hexanoate
Molecular weight	427.519
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	5.0
Synonyms	SCHEMBL16710636
Inchi Key	CUAVFYFSPYDLOY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25N3O4S/c1-3-19-24-25-14-16(23-22(25)30-19)18-13-15-9-8-10-17(21(15)29-18)28-12-7-5-6-11-20(26)27-4-2/h8-10,13-14H,3-7,11-12H2,1-2H3
PubChem CID	118070666
ChEMBL	CHEMBL3729522
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1467.0 nM	None	ChEMBL

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